Synthesis and biochemical studies of 19-oxygenated derivatives of 6α- and 6β-methylandrostenediones as catalytic probes for the active site of aromataseNUMAZAWA, Mitsuteru; YOSHIMURA, Akiko.Biological & pharmaceutical bulletin. 2000, Vol 23, Num 9, pp 1059-1065, issn 0918-6158Article

Synthesis of 19-oxygenated 4β, 5β-epoxy derivatives of 16α-hydroxyandrostenedione as mechanistic and catalytic probes for aromatase reactionNUMAZAWA, Mitsuteru; YOSHIMURA, Akiko.Chemical and pharmaceutical bulletin. 2000, Vol 48, Num 9, pp 1359-1362, issn 0009-2363Article

Probing the binding pocket of the active site of aromatase with 2-phenylaliphatic androsta-1,4-diene-3,17-dione steroidsTAKAHASHI, Madoka; YAMASHITA, Kouwa; NUMAZAWA, Mitsuteru et al.Steroids. 2010, Vol 75, Num 4-5, pp 330-337, issn 0039-128X, 8 p.Article

Chemical aromatization of 19-hydroxyandrosta-1,4-diene-3,17-dione with acid or alkaline : Elimination of the 19-hydroxymethyl group as formaldehydeNUMAZAWA, Mitsuteru; YAMASHITA, Kouwa; KIMURA, Nao et al.Steroids. 2009, Vol 74, Num 2, pp 208-211, issn 0039-128X, 4 p.Article

Synthesis of pyridine-carboxylate derivatives of hydroxysteroids for liquid chromatography-electrospray ionization-mass spectrometryYAMASHITA, Kouwa; KOBAYASHI, Sayuri; TSUKAMOTO, Satoshi et al.Steroids. 2007, Vol 72, Num 1, pp 50-59, issn 0039-128X, 10 p.Article

Structure-activity relationships of 2α-substituted androstenedione analogs as aromatase inhibitors and their aromatization reactionsNUMAZAWA, Mitsuteru; HANDA, Wakako; HASEGAWA, Chie et al.Journal of steroid biochemistry and molecular biology. 2005, Vol 97, Num 4, pp 353-359, issn 0960-0760, 7 p.Article

Fusaric Acid as a Novel Proton-Affinitive Derivatizing Reagent for Highly Sensitive Quantification of Hydroxysteroids by LC-ESI-MS/MSYAMASHITA, Kouwa; YAMAZAKI, Keiko; KOMATSU, Sachiko et al.Journal of the American Society for Mass Spectrometry. 2010, Vol 21, Num 2, pp 249-253, issn 1044-0305, 5 p.Article

Biochemical aromatization of 2-methyleneandrostenedione : Stereochemistry of hydrogen removal at the C-1 positionNUMAZAWA, Mitsuteru; HANDA, Wakako; MATSUZAKI, Hisao et al.Journal of steroid biochemistry and molecular biology. 2006, Vol 101, Num 4-5, pp 239-245, issn 0960-0760, 7 p.Article

Kinetic analysis of reversible inhibition of 16α-hydroxyandrostenedione aromatization in human placental microsomes by suicide substrates of androstenedione aromatizationNUMAZAWA, Mitsuteru; MUTSUMI, Ayako; TACHIBANA, Mii et al.Biological & pharmaceutical bulletin. 2003, Vol 26, Num 6, pp 890-892, issn 0918-6158, 3 p.Article

Improved synthesis and molecular modeling of 4β, 19-dihydroxyandrost-5-en-17-one, an excellent inhibitor of aromataseNUMAZAWA, Mitsuteru; YAMADA, Keiko; WATARI, Yoko et al.Chemical and pharmaceutical bulletin. 2002, Vol 50, Num 5, pp 703-705, issn 0009-2363Article

Studies on the catalytic function of aromatase: aromatization of 6-alkoxy-substituted androgensNUMAZAWA, Mitsuteru; ANDO, Momoko; ZENNYOJI, Rika et al.Journal of steroid biochemistry and molecular biology. 2002, Vol 82, Num 1, pp 65-73, issn 0960-0760, 9 p.Article

19-oxygenation of C₁₉-Steroids with an A, B-ring enone structure, competitive inhibitors of estrogen biosynthesis, with human placental aromataseNUMAZAWA, Mitsuteru; YAMADA, Keiko; NAGAOKA, Masao et al.Biological & pharmaceutical bulletin. 2001, Vol 24, Num 4, pp 332-335, issn 0918-6158Article

Gas chromatography-mass spectrometric determination of activity of human placental aromatase using 16α-hydroxyandrostenedione as a substrateNUMAZAWA, Mitsuteru; YOSHIMURA, Akiko; NAGAOKA, Masao et al.Biological & pharmaceutical bulletin. 2001, Vol 24, Num 5, pp 564-566, issn 0918-6158Article

Production of 16β-(acetoxy)acetoxy derivatives by reaction of 17-keto steroid enol acetates with lead (IV) acetateNUMAZAWA, Mitsuteru; SHELANGOUSKI, Momoko; NAKAKOSHI, Masamichi et al.Steroids. 2001, Vol 66, Num 10, pp 743-748, issn 0039-128XArticle

Probing the binding pocket of the active site of aromatase with 6-ether or 6-ester substituted androst-4-ene-3,17-diones and their diene and triene analogsNUMAZAWA, Mitsuteru; SHELANGOUSKI, Momoko; NAGASAKA, Mina et al.Steroids. 2000, Vol 65, Num 12, pp 871-882, issn 0039-128XArticle

4- and 6-(p-Sulphamoylphenyl)androstenediones: Studies of aromatase inhibitor-based oestrone sulphatase inhibitionWATARI, Yoko; YAMAGUCHI, Satoshi; TAKAHASHI, Madoka et al.Steroids. 2010, Vol 75, Num 12, pp 891-896, issn 0039-128X, 6 p.Article

Time-dependent aromatase inactivation by 4β, 5β-epoxides of the natural substrate androstenedione and its 19-oxygenated analogsNUMAZAWA, Mitsuteru; YOSHIMURA, Akiko; TACHIBANA, Mii et al.Steroids. 2002, Vol 67, Num 3-4, pp 185-193, issn 0039-128XArticle

Assay of labile estrogen o-quinones, potent carcinogenic molecular species, by high performance liquid chromatography-electrospray ionization tandem mass spectrometry with phenazine derivatizationYAMASHITA, Kouwa; MASUDA, Akina; HOSHINO, Yuka et al.Journal of steroid biochemistry and molecular biology. 2010, Vol 119, Num 3-5, pp 141-148, issn 0960-0760, 8 p.Article

6β,19-Bridged androstenedione analogs as aromatase inhibitorsKOMATSU, Sachiko; YAGUCHI, Ayaka; YAMASHITA, Kouwa et al.Steroids. 2009, Vol 74, Num 12, pp 884-889, issn 0039-128X, 6 p.Article

Mass spectrometric analysis of oxygenations in aromatization of androst-4-ene-3,6,17-trione, a suicide substrate of aromatase, by placental microsomes. isotope effect and stereochemistryNUMAZAWA, Mitsuteru; TAKAHASHI, Madoka; NAGAOKA, Masao et al.Journal of steroid biochemistry and molecular biology. 2007, Vol 107, Num 3-5, pp 220-227, issn 0960-0760, 8 p.Article

Probing the active site of aromatase with 2-methyl-substituted androstenedione analogsNUMAZAWA, Mitsuteru; WATARI, Yoko; YAMADA, Keiko et al.Steroids. 2003, Vol 68, Num 6, pp 503-513, issn 0039-128X, 11 p.Article

Aromatization of androstenedione and 16a-hydroxyandrostenedione in human placental microsomes Kinetic analysis of inhibition by the 19-oxygenated and 3-deoxy analogsNUMAZAWA, Mitsuteru; WATARI, Yoko; KOMATSU, Sachiko et al.Steroids. 2008, Vol 73, Num 12, pp 1262-1269, issn 0039-128X, 8 p.Article

Identification of 16α, 19-dihydroxyandrostenedione in the serum of pregnant women by gas chromatography-mass spectrometryNUMAZAWA, Mitsuteru; SATOH, Satoshi; NAGAOKA, Masao et al.Biological & pharmaceutical bulletin. 2001, Vol 24, Num 8, pp 947-949, issn 0918-6158Article

Aromatization of 16α-hydroxyandrostenedione by human placental microsomes: effect of preincubation with suicide substrates of androstenedione aromatizationNUMAZAWA, Mitsuteru; TACHIBANA, Mii; MUTSUMI, Ayako et al.Journal of steroid biochemistry and molecular biology. 2002, Vol 81, Num 2, pp 165-172, issn 0960-0760Article

Role of hydrophilic interaction in binding of hydroxylated 3-deoxy C₁₉ steroids to the active site of aromataseNUMAZAWA, Mitsuteru; YAMADA, Keiko; NITTA, Syoko et al.Journal of medicinal chemistry (Print). 2001, Vol 44, Num 24, pp 4277-4283, issn 0022-2623Article